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101.
The reaction of aldehydes with N-methylpyrrole carried out in the presence of catalytic pyrrolidinium tetrafluoroborate at room temperature affords the corresponding dipyrromethanes and minor amounts of tripyrranes. This new, mild, and convenient process represents the first organocatalytic synthesis of dipyrromethanes. The products are obtained in chemical yields similar to those obtained with existing methods, which, however, require either a much larger excess of heterocycle (when aldehydes are employed as starting materials), or more drastic reaction conditions (when aldehyde equivalents are used as starting materials) than those employed here. A mechanism is proposed to explain the course of this reaction. 相似文献
102.
3-Methylimidazolium tribromide proves to be an alternative highly efficient reagent/solvent for the halogenation of non-activated aromatic compounds. 相似文献
103.
Bianchi L Dell'Erba C Maccagno M Petrillo G Rizzato E Sancassan F Severi E Tavani C 《The Journal of organic chemistry》2005,70(22):8734-8738
[reaction: see text] In prosecution of previous work on the thermal cyclization of 1-aryl-4-methanesulfonyl-2-nitro-3-phenylsulfonyl-1,3-butadienes (7), the 3-unsubstituted derivatives 8, deriving from the initial ring opening of 3-nitrothiophene (2), have been likewise found herein to undergo cyclization, followed by aromatization, in analogous mild experimental conditions, leading to the ring-fused homo- or heteroaromatic nitro derivatives 10. The concerted electrocyclic nature of the process is strongly supported by the outcome of tests based on the variation of the polarity of the solvent or of the electron density on the aryl of 8. Thus, the successful application of the process to the non-phenylsulfonyl-activated 8 significantly widens the scope of a synthetically valuable overall ring-opening/ring-closing procedure from nitrothiophenes. Support to the recently renewed interest in thermal 6pi electrocyclizations as a tool for the construction of the benzene ring is furthermore provided. 相似文献
104.
105.
Cinzia Forni Massimiliano Rossi Ilaria Borromeo Giordana Feriotto Giovambattista Platamone Claudio Tabolacci Carlo Mischiati Simone Beninati 《Molecules (Basel, Switzerland)》2021,26(12)
Nutraceuticals are biologically active molecules present in foods; they can have beneficial effects on health, but they are not available in large enough quantities to perform this function. Plant metabolites, such as polyphenols, are widely diffused in the plant kingdom, where they play fundamental roles in plant development and interactions with the environment. Among these, flavonoids are of particular interest as they have significant effects on human health. In vitro and/or in vivo studies described flavonoids as essential nutrients for preventing several diseases. They display broad and promising bioactivities to fight cancer, inflammation, bacterial infections, as well as to reduce the severity of neurodegenerative and cardiovascular diseases or diabetes. Therefore, it is not surprising that interest in flavonoids has sharply increased in recent years. More than 23,000 scientific publications on flavonoids have described the potential anticancer activity of these natural molecules in the last decade. Studies, in vitro and in vivo, show that flavonoids exhibit anticancer properties, and many epidemiological studies confirm that dietary intake of flavonoids leads to a reduced risk of cancer. This review provides a glimpse of the mechanisms of action of flavonoids on cancer cells. 相似文献
106.
Cinzia Chiappe 《Monatshefte für Chemie / Chemical Monthly》2007,138(11):1035-1043
Summary. From an overview of the different theoretical and experimental methods it was possible to evidence the presence of aggregates
in ionic liquids (ILs), and to specify their role in determining the unique physical-chemical properties of these media. An
understanding of the structure of ILs, as pure compounds or in the presence of dissolved species, is fundamental if the reactivity
and selectivity in ILs mediated reactions is to become predictive. 相似文献
107.
108.
109.
In this paper we propose and implement numerical methods to detect exponential dichotomy on the real line. Our algorithms
are based on the singular value decomposition and the QR factorization of a fundamental matrix solution. The theoretical justification
for our methods was laid down in the companion paper: “Exponential Dichotomy on the real line: SVD and QR methods.” 相似文献
110.
Fontana A Viale M Guernelli S Gasbarri C Rizzato E Maccagno M Petrillo G Aiello C Ferrini S Spinelli D 《Organic & biomolecular chemistry》2010,8(24):5674-5681
Different nitronaphthylbutadienes have been previously proved to have antitumour activity. The main drawback of these derivatives is their low water solubility. With the aim of facilitating the administration of these new drugs we have synthesized the hexyl (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate analogue (1-Naph-NHCB) which is demonstrated to be easily included into cyclodextrins and/or entrapped into liposomes. Its antitumour activity was revealed to be almost comparable with that of the previously studied methyl analogue ester (1-Naph-NMCB). On the other hand, in vitro studies with different cancer cell lines showed that the cytotoxic activity of both 1-Naph-NMCB and 1-Naph-NHCB were fully preserved and in some cases also enhanced when entrapped into liposomal carriers. 相似文献